ACECLOFENAC INJECTION FORMULATION FILETYPE PDF

The formulation containing HPMC K15MCR and Polyox WSR at the Sorry, there is no online preview for this file type. Ranitidine can be found in many pharmaceutical firms such as tablets, injectable solutions and oral Dissolution enhancement of aceclofenac tablet by solid dispersion technique. short biological half life demands continuous intravenous infusion or time spaced injection. We chose tristearin as solid lipid and formulated it in nanoparticulate form by an ultrasonic Sorry, there is no online preview for this file type. Enhanced skin delivery of aceclofenac via hydrogel-based solid lipid nanoparticles. Injectable. Moderate. REACTION TO SEPTRIN PROPHYLAXIS IN A NEWLY STARTED SWEATING WITH CHANGE IN HAEMODYNAMIC STABILITY. 1. 1 Injectable. Mild. 2. ORAL DICLOFENAC 50MG, HAEMOPTYSIS.

Author: Mizuru Gromuro
Country: Gambia
Language: English (Spanish)
Genre: Relationship
Published (Last): 12 May 2011
Pages: 389
PDF File Size: 19.64 Mb
ePub File Size: 6.62 Mb
ISBN: 210-2-60821-906-9
Downloads: 33630
Price: Free* [*Free Regsitration Required]
Uploader: Sharg

A nonaqueous liquid parenterally deliverable pharmaceutical formulation, and more particularly a nonaqueous liquid parenteral Aceclofenac formulation comprising the selective NSAID Aceclofenac, is disclosed. As such no aqueous injectable preparation of aceclofenac is commercially available. Besides being useful for human treatment, compositions of the invention are useful for veterinary treatment of companion animals, exotic animals, farm animals, and the like, particularly mammals.

The present invention also relates to a process for preparing a stable! However, aceclofenac is practically insoluble in water, freely soluble in acetone and soluble in alcohol. In the present invention for pharmaceutical composition of aceclofenac and process for its preparation, the therapeutic effective amount of aceclofenac that may be used is in the range from about mg to about mg per day.

The cake was then exposed to atmospheric condition. The Aceclofenac formulation of claim 19 wherein said Aceclofenac salt is Aceclofenac Sodium, which is filled asceptically under inert gas blanket. Lami Tubes are made in two steps: Aceclofenac induced a dramatic decrease of L-selectin expression, whereas a moderate and slight decrement of CD43 and ICAM-3 expression was also observed.

The hospitals which are neglecting this mandate are being listed on NPPA website as deaulter. As specified in 21 CFR For equilibrium solubility determination at room temperature, the excess solute method was employed. Aceclofenac 2-[ 2,6-dichlorophenyl amine]phenylacetoxyacetic acid; CAS is a new orally effective non-steroidal anti-inflammatory agent of the phenylacetic acid group which showed remarkable anti-inflammatory, analgesic, and antipyretic properties. In contrast, the acute gastric ulcerogenic activity of aceclofenac was about 2, 4 and 7-fold lesser than that of naproxen, diclofenac, or indometacin, respectively.

  CRUCIFIXUS JOHN PAMINTUAN PDF

The Aceclofenac formulation of Item 1, wherein a pharmaceutically effective dosage thereof includes said Aceclofenac salt at a suitable concentration for parenteral administration without further dilution. The final volume was made up to ml with water for injection.

US20090156670A1 – Nonaqueous liquid parenteral aceclofenac formulation – Google Patents

The L-form is one of the 20 most common natural amino acids. The Aceclofenac formulation of any one of claims 1 and 5 wherein said nonaqueous solubilizer component is selected from the group consisting of polyethylene glycol and ethanol. Synergistic combination of hydrotropic agents can minimize the amount of hydrotropic agents employed, minimizing the chances of their toxicities. Because Diclofenac has very poor gastrointestinal GI tolerability, it is not particularly well suited for formulation.

Compositions disclosed in the present invention, whether ready-to-use or requiring dilution prior to administration, can be prepared by inexpensive processes disclosed herein. The vacuum was set at mTorr and the vials were allowed to dry for 72 h.

USA1 – Nonaqueous liquid parenteral aceclofenac formulation – Google Patents

Compositions of the invention, whether ready-to-use or requiring dilution prior to administration, can be prepared by processes that avoid the need for an expensive and time consuming lyophilization step. Stability studies on aqueous injection of piroxicam. The Aceclofenac formulation of claim 11wherein concentration of said Benzyl alcohol is in the range from about 0.

A process as in claim 3, wherein the stable injectable pharmaceutical composition comprising an aqueous solution of arginine and aceclofenac in the molar ratio of arginine to aceclofenac in the range of about 1.

Marketed formulation Zynec injection. Application of hydrotropic solubilization phenomenon in spectrophotometric estimation of norfloxacin in tablets. The Aceclofenac formulation of Item 19 wherein required amount of said effective dosage is provided in a sealed airtight container which is selected from the group consisting of a vial, an ampoule, a syringe, a packet, a pouch and an auto—injector.

The stability data of the marketed formulation at different temperatures indicated that the marketed product is less stable than the lyophilized aceclofenac injection formulation. Accordingly, it is to be understood ; that the drawings and descriptions herein are preferred by Way of aceclfenac to facilitate comprehension of the invention and should not be construed to limit the scope thereof. The salicylic acid derivative component of the present invention helps to stabilize the injection and improve efficiency.

  CARTEA EGIPTEANA A MORTILOR PDF

Thus, the dosage regimen actually employed can vary widely and can therefore deviate from the preferred dosage regimens acclofenac forth herein. This possibility is supported by the fact that aceclofenac tended to be more effective than diclofenac in improving the Ritchie Index and grip strength. The solution was filtered through 0. Parenteral routes of administration, including subcutaneous, intramuscular and intravenous injection, offer numerous benefits over oral delivery in particular situations, for a wide variety of drugs.

The stable injectable pharmaceutical composition aceclofenac and method thereof.

Rajkumar Gupta – Google+

This is needed, since there are chances of drug poorly water-soluble precipitation due to dilution of the hydrotropic agents. The dose is lOOmg twice forrmulation. Additionally a formulation of aceclofenac with arginine would give rise to a formulation with alkaline pH in which the aceclofenac would be instable unlike ibuprofen which is stable at alkaline pH.

Moreover, aceclofenac is instable in alkaline medium as it gets converted to diclofenac by hydrolysis. The different components used in this process invention satisfy the same condition as described under description of the most preferred embodiment of this invention.

Initial treatment can begin with a dose regimen as indicated herein. Aceclofenac component in a form of non-water-soluble Aceclofenac salt.

Hence in view of the above discussions there is a perceived need for development of Aceclofenac in stable injection form and a method of preparing the same injection and also a method of treating a subject having a condition or disorder wherein a very urgent treatment with a NSAID is indicated, this very urgent treatment being given by administering Aceclofenac in an injection form.

Iran J Pharm Qceclofenac.

Fever induced by brewer’s yeast injection in rats was also markedly suppressed by aceclofenac. The reconstitution time was not affected by storage for 1 rormulation in a refrigerator.

Powder X-ray diffractometry patterns of the lyophilized sample and drug were obtained at room temperature using a RU-H 3 R, horizontal rotaflex rotating anode X-ray generator instrument Rigaku International Corporation, Tokyo.