Cogan-Reese syndrome is a clinical variant of iridocorneal endothelial (ICE) syndrome (see this term) characterized by variable iris atrophy, pigmented and. This variant of ICE syndrome is distinguised by its Cogan-Reese sub-type of ICE syndrome. A YEAR-OLD woman was first diagnosed as having iridocorneal endothelial syndrome in She underwent a trabeculectomy in Photographs first.

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A sector iridectomy, which was performed at the time of GDI in our patient, should be considered in order to eliminate the tube being pulled or clogged by ICE-related membranes.

Iridocorneal Endothelial Syndrome and Secondary Glaucoma – EyeWiki

Trabeculectomy is commonly performed, but the success rates are poor and many patients We performed a trabeculectomy surgery for this patient with a well-functioning bleb to reduce the intraocular pressures following failure of topical anti-glaucoma medications.

Am J Ophthalmol ; Enroll in the International Ophthalmologists contest. The early identification of unilateral synerome should prompt a focused assessment for ICE syndrome, despite its erese prevalence.

Glaucoma may lead to vision loss. Together we are strong. Causes The cause of Cogan-Reese syndrome is not known.

Management of Cogan-Reese, similar to that of the other ICE syndromes, is aimed at slowing or preventing vision loss from secondary angle-closure glaucoma by lowering the patient’s intraocular pressure.

Iridocorneal Endothelial Syndrome and Secondary Glaucoma

This disorder most frequently appears in young and middle-aged females, usually affecting only one eye unilateral and developing slowly over time. Iris nevus Cogan-Reese syndrome: For all other comments, please send your remarks via contact us. Major characteristics of Cogan-Reese syndrome include a matted or smudged appearance to the surface of the iris nevusyellow or brown lumps or nodules on the iris nodular iris nevithe attachment of portions of the iris to the cornea peripheral anterior synechiaeand increased pressure in the eye glaucoma.


At that visit, her IOP was 57 mmHg, and there was evidence of anterior chamber inflammation. Other search option s Alphabetical list. Many had corneal edema, and all had changes in the iris consisting of one or more of the following: Specialised Social Services Eurordis directory.

Original article contributed by: Postoperative Complications and Long-Term Outcomes. Alterations of the corneal endothelium. Topical medication is the first line therapy for patients with elevated intraocular pressure from secondary angle-closure glaucoma in the setting of ICE syndrome.

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Cogan-Reese Syndrome: A Rare Case of Unilateral Glaucoma

These variants may represent different stages of one disease. Acetazolamide was restarted, and timolol and prednisolone forte were added.

ayndrome Corneal endothelial cell abnormalities in an early stage of the iridocorneal endothelial syndrome. A 45 year old female presented with redness, pain and diminision of vision in left eye. Herpes Simplex Virus has been found in a substantial number of patients with ICE syndrome yet is absent in normal corneal endothelium [3].

The iris findings of this variant can be quite robust and progressive over time. Slit lamp photo of the left eye shows corneal clouding secondary to diffuse stromal edema and bullous keratopathy. However, if corneal decompensation is severe, endothelial keratoplasty EK or penetrating keratoplasty PK is required.

Create a free personal account to access your subscriptions, sign up for alerts, and more. Mild cases can be managed dyndrome topical hypertonic saline drops and ointments. There is a hypothesis that ICE syndromes stem from an in-vitro herpes infection localized in the endothelial layer. Sign in to make a comment Sign in to your personal account.


This is dependent on the timing of diagnosis within the disease course, and the success or failure of treatment.

Most affected individuals are white. Pre-operatively, the patient was given mannitol due to her severely elevated IOP. Create a free personal account to download free article PDFs, sign up for alerts, and more. Unfortunately, this syndeome fails to adequately control intraocular pressure due to progressive obstruction of the trabecular meshwork.

The mechanism of glaucoma in ICE syndrome all three variants is believed to be related to a cellular membrane secreted by the abnormal endothelial cells.

Cogan Reese Syndrome – NORD (National Organization for Rare Disorders)

Concomitant control of IOP is vital for cogsn of corneal graft clarity. Specular microscopy of the left eye showed pleomorphism and polymegathism with multiple guttatae.

The patient may present with unilateral reduced vision, noticeable color changes to the iris, or unilateral secondary glaucoma due to corneal endothelium obstruction of the trabecular meshwork.

Corneal edema in ICE syndrome patients may be exacerbated by elevated IOP, and these corneal changes may benefit from the reduction of IOP by topical aqueous suppressants as well. The patient was completely evaluated for the complaints. The Cogan-Reese variant of the ICE syndromes is unique because of the pedunculated, pigmented nevi that present on the iris, in addition to the corneal edema, PAS, and ectropion uveae.