LUPUS TUMIDUS PDF

Lupus tumidus is considered a rare subtype of chronic cutaneous lupus erythematosus, characterized by erythema and bright urticarial erythematous- violaceous. Tumid lupus erythematosus (TLE), also known as lupus erythematosus tumidus, is a highly photosensitive form of cutaneous lupus erythematosus (cutaneous. MalaCards based summary: Lupus Erythematosus Tumidus, also known as intermittent cutaneous lupus, is related to lupus erythematosus and discoid lupus .

Author: Tazragore Mikall
Country: South Africa
Language: English (Spanish)
Genre: Art
Published (Last): 20 August 2014
Pages: 210
PDF File Size: 7.73 Mb
ePub File Size: 19.17 Mb
ISBN: 256-6-80813-231-7
Downloads: 55995
Price: Free* [*Free Regsitration Required]
Uploader: Meztijar

Direct immunofluorescence tests may show positive antibody deposition along the basement membrane lupus band test. Indian Dermatology Online Journal.

Follicular plugging and adherent hyperkeratotic scaling, which are also features of DLE, have not been seen in any of the patients. Lupus erythematosus is a multisystem, heterogeneous, autoimmune disease characterized by the production of autoantibodies against cellular constituents.

In 3 patients, the dose had to be increased to 6—6. Given her clinical presentation and histopathologic findings, a diagnosis of lupus erythematosus tumidus LET was made. Hypertrophic LE is a variant of discoid LE in which there are thickened and warty plaques resembling viral warts or skin cancers. Test areas were evaluated until specific lesions appeared for up to 4 weeks after the last irradiation.

In contrast to LET, histological features of Jessner’s lymphocytic infiltration of the skin show no interstitial mucin deposition, but varying numbers of plasma cells may be present.

Since the face is most often affected, LET obviously has a significant cosmetic implication.

Cutaneous lupus erythematosus

The prognosis for cutaneous LE is variable. LET is a photosensitive skin disease that is characterized by succulent, edematous, non-scarring plaques. The density of the infiltration differed from slight to moderate and, in some cases, scattered neutrophils were seen. Support Center Support Center. All of the biopsy specimens showed a distinct subepidermal edema and mucin deposition between collagen lupue Figure 4. Diagnostic features on biopsy are more likely to be found in LE-specific skin lesions than in LE-nonspecific cutaneous LE.

  EZTREND QXE PDF

Course of the disease and therapy. We describe a case of a year-old woman with systemic lupus erythematosus SLE and secondary class V lupus nephritis.

Lupus tumidus: a report of two cases

However, epidermal involvement usually was not found, and smudging of the dermoepidermal junction was only occasionally detected. Lupus erythematosus tumidus LET is a photosensitive skin disease characterized by succulent, edematous, and non-scarring plaques. Review of 80 patients. She was also being treated for biopsy proven class V lupus nephritis with mycophenolate mofetil mg twice a day, tacrolimus 2mg twice a day, and hydroxychloroquine sulfate mg daily 4.

You can help Wikipedia by expanding it. InGoerz et al 16 emphasized the extreme photosensitivity as a major characteristic feature of LET and detected a male tujidus with the peak of onset from 41 through 50 years of age. Archives of Dermatology Reader’s Choice: Lupus tumidus differs in several aspects from the other variants of CCLE, such as the absence of scars when involuted, epidermal atrophy and follicular plugging and adherent hyperkeratotic scaling, all of which are present with discoid lupus.

National Center for Biotechnology InformationU. What if there tumidhs a fourth recurrence?

The clinical distinction between PLE and LET can be difficult; however, LET shows a much more delayed reaction after sun exposure, and healing of skin lesions takes much longer, even when sun exposure is avoided and a sun block is applied daily.

We report two cases of lupus tumidus, which deserve attention for their low frequency in the literature, in addition to their relevance as a differential diagnosis among dermatologic disorders.

Sign in to make a comment Sign in to your personal account. The primary and the experimentally UV-induced skin lesions demonstrated perivascular and periadnexal superficial and deep lymphocytic infiltration Figure 3. The clinical picture, one of the major criteria of LET, is characterized by nonscarring, erythematous, succulent, urticarialike single or multiple plaques with no surface changes such as follicular plugging Figure 1.

Tumid lupus erythematosus – Wikipedia

None of the 40 patients had a history of drug-induced LET in our study after up to 15 years of follow-up. Epub Apr Antimalarials, Autoimmune diseases, Lupus erythematosus, cutaneous.

  BERIO SEQUENZA BASSOON PDF

Diagnostic Criteria of Lupus Erythematosus Tumidus. Chronic cutaneous LE causes facial deformity and scarring. LE is classified as autoimmuneas it is associated with pathogenic antibodies directed against components of cell nuclei in various tissues.

She had complete resolution with topical corticosteroids, however the lesions returned a month later and a low dose oral prednisone taper was required to achieve remission. Biopsies of the skin on the left frontal region and of the left nasolabial sulcus suggested the diagnosis of lupus tumidus. Nearly all the case reports of LET in the literature are published by European countries, especially Germany and France, indicating that many more white tjmidus are seen.

Author information Article notes Copyright and License information Lipus. A year-old caucasian woman with a one-year history of systemic lupus erythematosus SLE was referred to dermatology clinic for a persistent eruption of a rash on her face and arms.

Med Clin North Am. Histologic features of the major clinical variants of lupus erythematosus involving the skin. Since its first description inLET has been documented rarely in the literature, and its clinical importance has not been fully appreciated. The clinical picture, extreme photosensitivity, histological findings, and effective treatment with antimalarials are so characteristic that LET should be considered as a separate entity and differentiated from other variants of cutaneous LE.

The eruption had been present for one week and had occurred several months ago for a similar duration and had resolved without treatment or scarring. Please review our privacy policy.

Chronic cutaneous lupus erythematosus. J Am Acad Dermatol. The main differential diagnoses are luupus light eruption, Jessner’s lymphocytic infiltration of the skin, reticular erythematous mucinosis, and pseudolymphoma. Lupus tumidus is considered a rare subtype of chronic cutaneous lupus erythematosus, characterized by erythema and bright urticarial erythematous-violaceous lesions that leave no scars after regression.