Aditya Choudhary et al. Froin Syndrome. 1Aditya Choudhary, 2Manoj K Goyal, 3Manish Modi, 4Kanchan K Mukherjee, 5Chirag K Ahuja, 6Vivek Lal. Georges Froin (–), a French physician practising at the turn of the century, was the first to describe the xanthochromia and marked coagulation of. Froin Syndrome is characterized with xanthochromic CSF, high CSF protein content, complete blockage of CSF circulation. We reported our case of Froin.

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These findings were radiologically consistent with extradural spinal mass.

Open in a separate window. CSF material was obtained in a sterile way and samples were sent to biochemistry and microbiology laboratories for examination. Levels of CSF protein and cholesterol were high, but bacterial cells and malignant cells were not found in CSF culture. Cholesterol and triglyceride levels in the CSF rise in synxrome meningitis, pyogenic meningitis, viral encephalitis, and hydrocephalus. Email sybdrome New issue alert. In case of detecting abnormal CSF appearance in the course of lumbar punction done for spinal anesthesia, CSF samples should be sent to biochemistry and microbiology laboratories.

Author information Copyright and License information Disclaimer. Find articles by Mi-Woon Kim. Guillian-Barre syndrome GBS was considered as the most likely diagnosis and the patient was referred to lumbar puncture and further workup.

CSF is xanthochromic in spinal block, subarachnoidal hemorrhage SAHGuillian-Barre Syndrome, subdural hematoma, tumors acustic neurinomaacute purulent menigitidis, blood dyscrasias [ 2 ].

Froin’s syndrome – Wikipedia

Yellow discoloration and coagulation of the CSF was first described in meningitis by Georges Froin in and in spinal tumours by Max Nonne, 3 hence the name Nonne-Froin sign. The patient underwent extensive diagnostic testing in search of a primary tumour outside the central nervous system.


Valproic acid attenuates the risk of acute respiratory failure in patients with subarachnoid hemorrhage. CSF is normally clear and colorless. zyndrome

Languages Polski Edit links. MRI result was consistent with melanocytoma radiologically. By using this site, you agree to the Terms of Use synddome Privacy Policy. Close mobile search navigation Article navigation. Therefore, a tumor of the spine was a suspicious cause of the xanthochromia, and CSF evaluation was performed immediately after CSF collection.

Pseudo-Froin’s syndrome, xanthochromia with high protein level of cerebrospinal fluid

No motor or sensory abnormalities were found in the upper chest or upper extremities. Journal List Korean J Anesthesiol v.

This medical diagnostic article is a stub. The syndromme had suffered from paraplegia for 20 years because of a thoracic spine burst fracture T and dislocation.

A lumbar computed tomography CT was non-contributory. Receive exclusive offers and updates from Oxford Academic. Retrieved from ” https: The picture shows yellow discoloration of the cerebrospinal fluid xanthochromia of the CSF.

High protein content of CSF has many reasons.

Froin’s syndrome

Introduction Georges Froin reported in that xanthochromic cerebrospinal fluid CSF and coagulation caused meningeal irritation. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

More on this topic Harlequin nail. Patient was put into sitting position. No specific problems such as headache, reflex tachycardia, or sweating were observed in the perioperative period. The patient was currently scheduled for a urinary bladder wall biopsy. This case was synrome to be Pseudo-Froin’s syndrome without abnormal neurological findings, simply caused by interruption of CSF flow due to thoracic spine destruction and dislocation.


A clinical test formerly used synrrome evaluation syhdrome spinal stenosis is Queckenstedt’s maneuver. Nowadays, a magnetic resonance imaging is used for identification of CSF flow obstruction.

Spinal drug administration was done after CSF confirmation by aspiration. This is an frooin article distributed under the terms of the Creative Commons Attribution Non-Commercial License http: Adams RD, Victor M editors. Froin’s syndrome is characterized by marked cerebrospinal fluid CSF xanthochromia yellow discoloration of the CSF and hypercoagulability due to increased protein content.

Nonne-Froin sign | QJM: An International Journal of Medicine | Oxford Academic

Yellow discoloration of the CSF, xanthochromia, is most commonly associated with subarachnoid hemorrhage, where red blood cells in the CSF haemolyse and release oxyhaemoglobin, which is then converted to bilirubin, thus the yellow discoloration. We obtained cranial and spinal MRI in order to support the diagnosis. Froin Syndrome was suggested according to these findings. It is caused by meningeal irritation e.

Can’t read the image? The CSF studies were performed within 30 min after collection of the fluid. This page was last edited on 2 Augustat His lumbar puncture revealed a yellow cerebrospinal fluid CSF that became instantly gelatinous Syndrkme 1A.

InMax Nonne explained spinal cord blockage related with high protein content. Guidelines Upcoming Special Issues.